Polythiazide

Polythiazide
Clinical data


AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601101
ATC code	C03AA05 (WHO)
Identifiers
IUPAC name 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
CAS Number	346-18-9^Y
PubChem (CID)	4870
IUPHAR/BPS	7274
ChemSpider	4704^N
UNII	36780APV5N^N
KEGG	D00657^N
ChEMBL	CHEMBL1587^N
ECHA InfoCard	100.005.881
Chemical and physical data
Formula	C₁₁H₁₃ClF₃N₃O₄S₃
Molar mass	439.88 g/mol
^NY (what is this?) (verify)

Polythiazide is a thiazide diuretic.^[1]^[2] A diuretic is any substance that promotes the production of urine.

References

↑ O'Brien, E. T.; MacKinnon, J. (1972). "Propranolol and polythiazide in treatment of hypertension". British heart journal. 34 (10): 1042–1044. doi:10.1136/hrt.34.10.1042. PMC 458544. PMID 5086971.
↑ Monroy, A.; Plata, C.; Hebert, S. C.; Gamba, G. (2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: A new model for ions and diuretics interaction". American Journal of Physiology. Renal Physiology. 279 (1): F161–F169. PMID 10894798.

Symporter inhibitors

Na⁺-Cl⁻	Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide; Others: Chlortalidone (chlorthalidone) Metolazone

Na⁺-K⁺-Cl⁻	Bumetanide Furosemide

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# Bumetanide Etacrynic acid Etozolin Muzolimine Ozolinone Piretanide Tienilic acid Torasemide

Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide^# Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide

Thiazide-likes (primarily DCT)	Quinethazone Clopamide Chlortalidone Mefruside Clofenamide Metolazone Meticrane Xipamide Indapamide Clorexolone Fenquizone

ESC blockers	Amiloride^# Triamterene Benzamil

Aldosterone antagonists	Spirolactones: Spironolactone^# Eplerenone Potassium canrenoate Canrenone Non-steroidal: Finerenone

Other

This article is issued from Wikipedia - version of the 2/15/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.