| Route | 
Location | 
Replaced by | 
Notes | 
US 2N US 2S | 
Arvilla to Grand Forks, North Dakota | 
US 2 CR 4 | 
Existed in 1931 | 
| US 6N | 
Port Jervis to Kingston, New York | 
NY 279 / US 209 | 
Existed in 1928–1933 | 
| US 6N | 
Erie to Waterford, Pennsylvania | 
PA 97 | 
Existed in 1931–1935 | 
| US 9E | 
Fort Lee, New Jersey to Glens Falls, New York | 
NY 254 / US 4 / US 9 / Route 5 | 
Existed in 1926–1930 | 
| US 9W | 
Keeseville to Elizabethtown, New York | 
NY 3 / NY 9W / NY 9N | 
Existed in 1928–1929 | 
US 10N US 10S | 
Moorhead to St. Cloud, Minnesota | 
US 218 / US 10 US 10 / US 52 / MN 27 / MN 153 | 
Existed in 1926–1934 | 
US 10N US 10S | 
Garrison to Three Forks, Montana | 
MT 287 / US 287 / US 12 US 10 / MT 2 / I‑90 | 
Existed in 1928–1960 | 
US 20N US 20S | 
Bridgewater Center to Busy Corners, Ohio | 
SR 120 / SR 51 / US 20 US 20 / US 20 Alt. / SR 107 / SR 576 | 
Existed in 1931–1935 Existed in 1933–1935 | 
US 25E US 25W | 
Richmond to Newport, Kentucky | 
US 27 / US 227 / KY 627 US 25 | 
Existed in 1926–1928 | 
| US 26N | 
Bayard to Broadwater, Nebraska | 
US 26 / US 385 | 
Existed in 1934–1959 | 
US 30N US 30S | 
Burley, Idaho to Granger, Wyoming | 
US 30 I‑80 / I‑84 (west) / US 89 / SR-30 / SR-42 / SH-81 | 
Existed in 1926–1972 | 
| US 30N | 
Huntington, Oregon to Fruitland, Idaho | 
US 95 / US-95 Spur / US 630 | 
Existed in 1926–1980 | 
| US 30S | 
Ontario to Nyssa, Oregon | 
US 20 / US 26 | 
Existed in 1938–1940 | 
US 30N US 30S | 
Delphos to Mansfield, Ohio | 
US 30 SR 430 / SR 309 | 
Existed in 1932–1975 Existed in 1931–1975 | 
| US 30S | 
Fremont, Nebraska to Missouri Valley, Iowa | 
US 75 / US 30 Alt. / Iowa 183 / US 6 / US 275 / N-130 / N-64 | 
Existed in 1931–1939 | 
US 40N US 40S | 
Limon, Colorado to Manhattan, Kansas Grand Junction, Colorado to Manhattan, Kansas | 
US 24 / K-194 K-18 / US 40 / K-140 / SH 71 / US 24 / I‑70 | 
Existed in 1926–1935 | 
US 41E US 41W | 
Cass Station, Georgia to Chattanooga, Tennessee | 
US 27 / US 411 / SR 20 / SR 293 US 41 | 
Existed in 1930–1933 Existed in 1926–1934 | 
US 41E US 41W | 
Hopkinsville, Kentucky to Nashville, Tennessee | 
US 41 US 43 / US 41A | 
Existed in 1929–1943 | 
| US 41E | 
Marietta to Atlanta, Georgia | 
US 41 / Hemphill Road | 
Existed in 1948 | 
US 49E US 49W | 
Brooklyn to Hattiesburg, Mississippi | 
US 49 Old US 49 / Old US 49W | 
Existed in 1930–1936 | 
US 50N US 50S | 
Garden City to Baldwin City, Kansas | 
US-56 / US-156 / K-156 US-59 / K-68 / US-75 / I-35 / US-50 | 
Existed in 1926–1957 | 
US 50N US 50S | 
Athens, Ohio to Ellenboro, West Virginia | 
US 50 Alternate / WV 16 / SR 7 / SR 550 WV 16 / WV 31 / US 50 | 
Existed in 1929–1935 | 
US 67E US 67W | 
Arkadelphia to Donaldson, Arkansas | 
AR 51 US 67 | 
Existed in 1931–1932 | 
US 67E US 67W | 
North Little Rock to Rixey, Arkansas | 
AR 161 / US 70 / US 165 AR 107 | 
Existed in 1935–1960 | 
US 67E US 67W | 
Morning Sun to Judsonia, Arkansas | 
AR 87 / AR 11 / US 67 AR 385 / US 67C | 
Existed in 1931–1949 | 
US 70N US 70S | 
Nashville to Sparta, Tennessee | 
US 70N / SR 26 / US 70 US 70 Alt. / US 70 / SR 1 / US 70S | 
Existed in 1929–1935 | 
| US 70N | 
Randlett to Wilson, Oklahoma | 
SH-76 / SH-53 / SH-5 / US-277 | 
Existed in 1936–1938 | 
US 73E US 73W | 
Oswego to Horton, Kansas | 
US-73 / US-40 / US-69 / K-96 US-159 / US-59 / US-169 / K-146 / K-47 / US-400 / US-59 | 
Existed in 1926–1935 | 
US 73E US 73W | 
Tekamah to Winnebago, Nebraska | 
US 73 / US 75 US 77 / N-32 | 
Existed in 1935–1957 | 
US 78N US 78S | 
Heflin, Alabama to Villa Rica, Georgia | 
US 78 US 78 Alternate / SR 61 / SR 166 / SR 46 | 
Existed in 1926–1934 | 
| US 80N | 
Abilene to Metcalf Gap, Texas | 
Alt. US 80 / US 180 / SH 351 | 
Existed in 1931–1934 | 
| US 85E | 
Mule Creek Junction, Wyoming to Lead, South Dakota | 
US 85 Alternate / US 18 / US 385 | 
Existed in 1931–1937 | 
US 87E US 87W | 
Armington, Montana to Muddy Gap, Wyoming | 
US 87 / MT 451 / WYO 196 / WYO 220 US 26 / US 89 / US 287 / WYO 138 / WYO 789 | 
Existed in 1926–1939 Existed in 1926–1935 | 
US 95E US 95W | 
Potlatch to Coeur d'Alene, Idaho | 
US-95 Alternate / I-90 / SH-97 / SH-3 / SH-6 US-95 | 
Existed in 1927–1935 Existed in the 1930s | 
US 99E US 99W | 
Portland to Junction City, Oregon | 
US 99 / OR 99E / I-5 US 99 Alt. / OR 99W | 
Existed in 1930–1972 | 
US 99E US 99W | 
Sacramento to Red Bluff, California | 
US 99 Alt. / SR 99 / SR 65 / I-80 / I-80 Bus. / SR 36 / SR 20 / SR 70 US 99 / I-5 / SR 113 / I-80 / SR 275 | 
Existed in 1928–1968 | 
US 99E US 99W | 
Manteca to Stockton, California | 
US 99 / SR 99 I-5 / US 50 | 
Existed in 1929–1933 | 
US 101E US 101W | 
San Francisco to San Jose, California | 
I-80 / I-880 / US 40 / US 50 / US 101 Alt. US 101 | 
Existed in 1929–1935 | 
US 101E US 101W | 
La Jolla to San Diego, California | 
I-5 / US 101 La Jolla Boulevard | 
Existed in 1934–1936 | 
| US 112S | 
Rolling Prairie, Indiana to Union, Michigan | 
SR 2 / SR 19 / M-205 | 
Existed in 1933–1934 | 
| US 281S | 
Oberon to Lallie, North Dakota | 
35th Street and 64th Avenue | 
Existed in 1939 |