Two-pore channel

two pore segment channel 1
Identifiers
Symbol	TPCN1
IUPHAR	392
Entrez	53373
HUGO	18182
OMIM	609666
RefSeq	NM_017901
UniProt	Q9ULQ1
Other data
Locus	Chr. 12 q24.21

two pore segment channel 2
Identifiers
Symbol	TPCN2
IUPHAR	393
Entrez	219931
HUGO	20820
RefSeq	NM_139075
UniProt	Q8NHX9
Other data
Locus	Chr. 11 q13.1

Two-pore channels are a small family of cation-selective ion channels, with two known paralogs in the human genome.^[1] They contain two tandem K_V-style six-transmembrane domains fused on one polypeptide chain that form a dimers in the membrane.^[2]^[3] These channels are closely related to CatSper channels and, more distantly, to TRP channels.

TPC channels are found in both animal ^[4] and plant ^[5] cells. In mammalian cells, recent evidence has identified the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP. The TPCN genes are distinct from the KCNK genes encoding the Tandem pore domain potassium channels.

References

↑ Yu, Frank H; Catterall, William A (2004). "The VGL-chanome: a protein superfamily specialized for electrical signaling and ionic homeostasis". Science STKE. 253: re15. doi:10.1126/stke.2532004re15. Retrieved 2016-02-02.
↑ Guo, J; Zeng, W; Chen, Q; Lee, C; Chen, L; Yang, Y; Cang, C; Ren, D; Jiang, Y (10 March 2016). "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana.". Nature. 531 (7593): 196–201. doi:10.1038/nature16446. PMC 4841471. PMID 26689363.
↑ Kintzer, AF; Stroud, RM (10 March 2016). "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana.". Nature. 531 (7593): 258–62. doi:10.1038/nature17194. PMID 26961658.
↑ Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochem. Biophys. Res. Commun. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632.
↑ Hedrich, R; Neher, E (1987). "Cytoplasmic calcium regulates voltage-dependent ion channels in plant vacuoles". Nature. 329: 833–836. doi:10.1038/329833a0.

External links

TPCN1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
AtTPC1 channel, Arabidopsis at the US National Library of Medicine Medical Subject Headings (MeSH)
"CatSper and Two-Pore Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3

Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ

Proton-gated	Amiloride-sensitive cation channel 1 2 3 4

Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1

Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1

Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18

Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker gene

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B

H⁺: Proton channel	HVCN1

M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4

M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6

H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family

Cytoplasm: Gap junction	Connexin: A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4) Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This article is issued from Wikipedia - version of the 7/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.