Terizidone

Terizidone
Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	C
ATC code	J04AK03 (WHO)
Identifiers
IUPAC name 4,4'-{1,4-Phenylenebis[(E)methylylidene (E)azanylylidene]}bis(1,2-oxazolidin-3-one)
Synonyms	4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
CAS Number	25683-71-0^N
PubChem (CID)	65720
ChemSpider	59144^Y
UNII	1199LEX5N8^Y
KEGG	D07247^Y
ECHA InfoCard	100.042.882
Chemical and physical data
Formula	C₁₄H₁₄N₄O₄
Molar mass	302.286 g/mol
3D model (Jmol)	Interactive image
SMILES O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2
InChI InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+^Y Key:ODKYYBOHSVLGNU-IAGONARPSA-N^Y
^NY (what is this?) (verify)

Terizidone is a drug used in the treatment of tuberculosis.^[1] Terizidone is used mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivate of cycloserine and it is bacteriostatic.^[2]

References

↑ "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Med. 82 (7-8): 477–81. 1991. PMID 1922892.
↑ Rossiter, Dawn (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.

Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)

Nucleic acid inhibitor

Rifamycins/ RNA polymerase inhibitor	Rifampicin^# Rifabutin Rifapentine Rifalazil^§

Antifolates/DSI	Dapsone^# Acedapsone Aldesulfone sodium

ASA	4-Aminosalicylic acid^# (Calcium aminosalicylate Sodium aminosalicylate)

Protein synthesis inhibitor

Aminoglycosides	Amikacin^# Capreomycin^# Kanamycin^# Streptomycin^#

Oxazolidone	Linezolid

Cell envelope antibiotic

Peptidoglycan layer	Alanine analogue: Cycloserine^#

Arabinogalactan layer	Ethylenediamine/arabinosyltransferase inhibitor: Ethambutol^# SQ109^†

Mycolic acid layer	Hydrazides/mycolic acid synth. inhibition: Isoniazid^# Thiocarbamides: Ethionamide^# Prothionamide Thiocarlide

Other/unknown

Combinations

Rifampicin/isoniazid/pyrazinamide

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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