Phosphodiesterase I
| Phosphodiesterase I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.4.1 | ||||||||
| CAS number | 9025-82-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Phosphodiesterase I (EC 3.1.4.1, 5'-exonuclease, 5'-phosphodiesterase, 5'-nucleotide phosphodiesterase, oligonucleate 5'-nucleotidohydrolase, 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-NPDase, 5'-PDase, 5'-PDE, 5'NPDE, alkaline phosphodiesterase, nucleotide pyrophosphatase/phosphodiesterase I, orthophosphoric diester phosphohydrolase, PDE I, phosphodiesterase, exonuclease I) is an enzyme with systematic name oligonucleotide 5'-nucleotidohydrolase.[1] This enzyme catalyses the following chemical reaction
- Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides.
See also
References
- ↑ Khorana, G.H. (1961). "Phosphodiesterases". In Boyer PD, Lardy H, Myrbäck K. The Enzymes. 5 (2nd ed.). New York: Academic Press. pp. 79–94.
External links
- Phosphodiesterase I at the US National Library of Medicine Medical Subject Headings (MeSH)
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