Pheophorbide A

Pheophorbide A
Names

IUPAC name (3S,4S)-9-Ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid
Identifiers
CAS Number	15664-29-6
3D model (Jmol)	Interactive image
ChEBI	CHEBI:38257
ChemSpider	10343120
ECHA InfoCard	100.036.110
EC Number	239-738-5
KEGG	C18021
PubChem	5323510
InChI InChI=1S/C35H36N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/h8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/b22-12-,23-13-,24-12-,25-14-,26-13-,27-14-,32-30-/t17-,21-,31+/m0/s1 Key: NSFSLUUZQIAOOX-QEWKCGBTSA-N InChI=1/C35H36N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(40)41)32(38-24)30-31(35(43)44-7)34(42)29-18(6)25(39-33(29)30)14-27-20(9-2)16(4)23(37-27)13-26(19)36-22/h8,12-14,17,21,31,36,39H,1,9-11H2,2-7H3,(H,40,41)/b22-12-,23-13-,24-12-,25-14-,26-13-,27-14-,32-30-/t17-,21-,31+/m0/s1 Key: NSFSLUUZQIAOOX-QEWKCGBTBX
SMILES CCC1=C(/c/2c/c3c(c(c([nH]3)/cc/4\nc(c5c6c(c(/c(/[nH]6)c/c1n2)C)C(=O)[C@@H]5C(=O)OC)[C@H]([C@@H]4C)CCC(=O)O)C)C=C)C
Properties
Chemical formula	C₃₅H₃₆N₄O₅
Molar mass	592.68 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Pheophorbide a is the product of chlorophyll breakdown. It is used as a photosensitizer.^[1]

Photodynamic therapy (PDT) with several photosensitizers is a promising modality for the treatment of cancer. In this study, the therapeutic effect of PDT using the synthetic photosensitizer pheophorbide a (Pa-PDT) was examined in AT-84 murine oral squamous cell carcinoma (OSCC) cells.

References

↑ Chen, K.; et al. (2009). "Novel photosensitizer-protein nanoparticles for Photodynamic therapy: Photophysical characterization and in vitro investigations". Journal of Photochemistry and Photobiology B: Biology. 96 (1): 66–74. doi:10.1016/j.jphotobiol.2009.04.006.

Types of tetrapyrroles

Bilanes
(Linear)

Phytobilins

Phytochromobilin

Phycobilins	Phycoerythrobilin Phycocyanobilin Phycourobilin Phycoviolobilin

Macrocycle

Corrinoids

Porphyrins

Protoporphyrins	Protoporphyrin IX Heme (b, c, a, o) Zinc protoporphyrin Magnesium protoporphyrin

Phytoporphyrins	Chlorophyll c Protochlorophyllide

Reduced
porphyrins

Porphyrinogens	Uroporphyrinogen (I, III) Coproporphyrinogen (I, III) Protoporphyrinogen IX

Chlorins	Chlorophyllide (a, b) Chlorophyll (a, b) Phaeophytin (a, b) Bacteriochlorophyll c

Bacteriochlorins	Bacteriochlorophyll a

Isobacteriochlorins	Siroheme Sirohydrochlorin

Corphins	Cofactor F430

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