Myelin-associated glycoprotein

MAG

Identifiers

MAG, GMA, S-SIGLEC-4A, SIGLEC4A, SPG75, myelin associated glycoprotein

External IDs

OMIM: 159460 MGI: 96912 HomoloGene: 1771 GeneCards: MAG

Gene ontology
Molecular function	• receptor binding • protein kinase binding • carbohydrate binding
Cellular component	• cytoplasm • integral component of membrane • membrane • myelin sheath • myelin sheath adaxonal region • Schmidt-Lanterman incisure • paranode region of axon • mesaxon • plasma membrane
Biological process	• negative regulation of neuron projection development • negative regulation of neuron differentiation • substantia nigra development • positive regulation of astrocyte differentiation • nervous system development • positive regulation of myelination • cellular response to mechanical stimulus • negative regulation of axonogenesis • cell adhesion • leukocyte migration
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4099


17136

Ensembl


ENSG00000105695


ENSMUSG00000036634

UniProt


P20916


P20917

RefSeq (mRNA)


NM_080600 NM_001199216 NM_002361


NM_010758

RefSeq (protein)


NP_001186145.1 NP_002352.1 NP_542167.1


NP_034888.1

Location (UCSC)

Chr 19: 35.29 – 35.31 Mb

Chr 7: 30.9 – 30.91 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

myelin associated glycoprotein
Identifiers
Symbol	MAG
Alt. symbols	GMA
Entrez	4099
HUGO	6783
OMIM	159460
RefSeq	NM_080600
UniProt	P20916
Other data
Locus	Chr. 19 q13.1

Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR.^[3] MAG is believed to be involved in myelination during nerve regeneration.^[4]

External links

Myelin-associated glycoprotein at the US National Library of Medicine Medical Subject Headings (MeSH)

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Quarles RH (2007). "Myelin-associated glycoprotein (MAG): past, present and beyond". Journal of Neurochemistry. 100 (6): 1431–48. doi:10.1111/j.1471-4159.2006.04319.x. PMID 17241126.
↑ Barton D, Arquint M, Roder J, Dunn R, Francke U (1987). "The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice". Genomics. 1 (2): 107–12. doi:10.1016/0888-7543(87)90002-4. PMID 2447011.

Protein: lectins

Animal

C-type lectins	Asialoglycoprotein receptor KLRD1 Collectin Mannan-binding lectin Mannose receptor proteochondroitin sulfate Aggrecan Versican Brevican Neurocan

Other	Calnexin Calreticulin CD22 CD33 Galectin Myelin-associated glycoprotein N-Acetylglucosamine receptor Selectin Sialoadhesin

Plant

Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)

Arrestin	SAG ARRB1 ARRB2 ARR3

Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18

Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero

Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C

Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34

Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF

see also other cell membrane protein disorders

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Myelin-associated glycoprotein

See also

External links

References