Molybdopterin synthase
| Molybdopterin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.1.12 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Molybdopterin synthase (EC 2.8.1.12, MPT synthase) is an enzyme required to synthesize molybdenum cofactor (MoCo) from precursor Z (now known as cyclic pyranopterin monophosphate).[1][2] This enzyme catalyses the following chemical reaction
- cyclic pyranopterin monophosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + H2O molybdopterin + 2 molybdopterin-synthase sulfur-carrier protein
It is heterodimeric and coded for by the MOCS2 gene.[3]
References
- ↑ Daniels, J.N.; Wuebbens, M.M.; Rajagopalan, K.V.; Schindelin, H. (2008). "Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency". Biochemistry. 47: 615–626. doi:10.1021/bi701734g. PMID 18092812.
- ↑ Wuebbens, M.M.; Rajagopalan, K.V. (2003). "Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis". J. Biol. Chem. 278: 14523–14532. doi:10.1074/jbc.m300453200. PMID 12571226.
- ↑ Sloan, J; Kinghorn, JR; Unkles, SE (1999). "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames". Nucleic Acids Research. 27 (3): 854–8. doi:10.1093/nar/27.3.854. PMC 148257
. PMID 9889283.
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