| Title | Released | Developer | Publisher | 
| I Have No Mouth, and I Must Scream | 1995 | The Dreamers Guild | Cyberdreams | 
| I of the Dragon | 2004 | Primal Software | Strategy First | 
| I Spy Spooky Mansion | 2005 | Scholastic | Scholastic | 
| I Spy Spooky Mansion Deluxe | 2005 | Scholastic | Scholastic | 
| I Wanna Be the Guy | 2007 | Michael "Kayin" O'Reilly |  | 
| I'm O.K – A Murder Simulator | 2005 | Thompsonsoft | Thompsonsoft | 
| I-Ninja | 2003 | Argonaut Games | Namco, Sony Computer Entertainment, Zoo Digital Publishing | 
| I-War, Independence War | 1997 | Particle Systems Ltd. | Infogrames | 
| I.G.I.-2: Covert Strike | 2003 | Innerloop Studios | Codemasters | 
| Ice Station Santa | 2007 | Telltale Games | Telltale Games | 
| Iced! | 2008 | Breakthrough | Breakthrough | 
| Icewind Dale | 2000 | Black Isle Studios | Interplay Entertainment | 
| Icewind Dale II | 2002 | Black Isle Studios | Interplay Entertainment | 
| Icewind Dale: Heart of Winter | 2001 | Black Isle Studios | Interplay Entertainment | 
| Ignition | 1995 | Unique Development Studios | Virgin Interactive | 
| Igor | 2004 | Think!Ware Development | Elmer Productions | 
| IL-2 Sturmovik | 2001 | 1C:Maddox Games | 1C, Ubisoft | 
| IL-2 Sturmovik: Forgotten Battles | 2003 | 1C:Maddox Games | 1C, Ubisoft | 
| Imagine: Animal Doctor | 2007 | Ubisoft | Ubisoft | 
| Imagine: Fashion Designer | 2007 | Ubisoft | Ubisoft | 
| Immaterial and Missing Power | 2004 | Twilight Frontier | Twilight Frontier | 
| Immortal Cities: Children of the Nile | 2004 | Tilted Mill Entertainment | Myelin Media, SEGA | 
| Imogen | 2003 | Ovine by Design | Ovine by Design | 
| Imperialism | 1997 | Frog City Software | Strategic Simulations, Inc. | 
| Imperialism II: Age of Exploration | 1999 | Frog City Software | Strategic Simulations, Inc. | 
| Imperishable Night | 2004 | Team Shanghai Alice | Team Shanghai Alice | 
| Imperium Galactica II: Alliances | 2000 | Digital Reality | GT Interactive | 
| Imperium Romanum | 2008 | Haemimont Games | Kalypso Media, Southpeak Interactive | 
| Imperivm III: Great Battles of Rome | 2005 | Haemimont Games | FX Interactive | 
| Impossible Creatures | 2003 | Relic Entertainment | Microsoft Game Studios | 
| Impressionists | 1997 | Index+ | Index+ | 
| In Cold Blood | 2000 | Revolution Software | Ubisoft, DreamCatcher Games | 
| In Memoriam | 2003 | Lexis Numerique | Ubisoft, The Adventure Company | 
| In the 1st Degree | 1995 | Adair & Armstrong | Broderbund | 
| In the Groove | 2004 | Roxor Games | Roxor Games, RedOctane | 
| In the Hunt | 1993 | Kokopeli | Kokopeli | 
| Incoming | 1998 | Rage Software | Interplay Entertainment, Imagineer | 
| Incoming Forces | 2002 | Rage Software | Hip Interactive | 
| The Incredible Hulk | 2008 | Edge of Reality | Sega | 
| The Incredibles | 2004 | Heavy Iron Studios | THQ, D3, Capcom | 
| The Incredibles: Rise of the Underminer | 2005 | Yuke's, Pacific Coast Power & Light | THQ, Capcom | 
| The Incredibles: When Danger Calls | 2004 | ImaginEngine | THQ | 
| Incubation: Time Is Running Out | 1997 | Blue Byte | Blue Byte | 
| Independence Day | 1997 | Radical Entertainment | Fox Interactive | 
| Independence War 2: Edge of Chaos | 2001 | Particle Systems Ltd. | Infogrames | 
| Indiana Jones and His Desktop Adventures | 1996 | LucasArts | LucasArts | 
| Indiana Jones and the Emperor's Tomb | 2003 | The Collective, Inc. | LucasArts | 
| Indiana Jones and the Infernal Machine | 1999 | LucasArts | LucasArts, THQ | 
| Industry Giant | 1998 | JoWood Productions | Interactive Magic | 
| Industry Giant II | 2002 | JoWood Productions | JoWood Productions | 
| Industryplayer | 2007 | Thomas Lehnert | Tycoon Sistemas Ltda | 
| Infantry | 1999 | Harmless Games LLC | Sony Online Entertainment | 
| Infernal | 2007 | Metropolis Software | Playlogic International | 
| Infinity Online | 2006 | Windysoft | game & game | 
| Inherit the Earth: Quest for the Orb | 1994 | The Dreamers Guild | New World Computing | 
| Inkawar | 2007 | Luis Grimaldo |  | 
| Inner Worlds | 1996 | Sleepless Software | Sleepless Software | 
| Inquisition | 2003 | Wanadoo Edition | Wanadoo Edition | 
| Insaniquarium | 2004 | Flying Bear Entertainment | PopCap Games | 
| Insecticide | 2008 | Crackpot Entertainment, Creat Studios, Inc. | Gamecock Media Group | 
| Insurgency: Modern Infantry Combat | 2007 | Insurgency Team | Valve Corporation | 
| Intellivision Lives! | 1998 | Intellivision Productions | Intellivision Productions | 
| Intellivision Rocks | 2001 | Intellivision Productions | Intellivision Productions | 
| International Cricket Captain | 1998 | Empire Interactive | Empire Interactive | 
| International Cricket Captain 2006: Ashes Edition | 2006 | Chris Child, Andy Yau | Xplosiv | 
| International Cricket Captain 2009 | 2009 | 2P Games | Childish Things | 
| International Cricket Captain III | 2007 | Empire Interactive | Empire Interactive | 
| International Cue Club | 2003 | Midas Interactive | Midas Interactive | 
| International Online Soccer, mod for Half-Life | 2002 | I.O.S. Team | I.O.S. Team | 
| International Superstar Soccer 3 | 2003 | KCEO | Konami | 
| Interpol: The Trail of Dr. Chaos | 2007 | TikGames | Sierra Online | 
| Interstate '76 | 1997 | Activision | Activision | 
| Interstate '76 Nitro Pack | 1997 | Activision | Activision | 
| Interstate '82 | 1999 | Activision | Activision | 
| Invadazoid | 2005 | Bantam City Games | Reflexive | 
| Iro ni Ide ni Keri Waga Koi wa | 2010 | Windmill | Windmill | 
| Iron Grip: Warlord | 2008 | Isotx | Isotx | 
| Iron Helix | 1993 | Drew Pictures | Spectrum Holobyte | 
| Iron Man | 2008 | Artificial Mind and Movement | Sega | 
| Iron Storm | 2002 | 4X Studios, Kylotonn | Dreamcatcher Interactive, Wanadoo Edition | 
| Iron Warriors: T-72 Tank Commander | 2004 | IDDK/Crazy House | Battlefront.com | 
| Ironclads: American Civil War | 2008 | Totem Games | Totem Games | 
| Island Xtreme Stunts | 2002 | Silicon Dreams Studio | Lego Software | 
| İstanbul Efsaneleri: Lale Savaşçıları | 1994 | SiliconWorx | Raks New Media | 
| Istaria: Chronicles of the Gifted | 2003 | Artifact Entertainment | Artifact Entertainment, Virtrium LLC, Tulga Games, LLC, EI Interactive | 
| The Italian Job | 2001 | Pixelogic | SCi, Global Star Software | 
| The Italian Job | 2003 | Climax Group | Eidos Interactive |