Gemopatrilat

Gemopatrilat
Names


IUPAC name [(6S)-2,2-dimethyl-7-oxo-6-{[(2S)-3-phenyl-2-sulfanylpropanoyl]amino}azepan-1-yl]acetic acid
Identifiers
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL107747^Y
ChemSpider	8061752^Y
PubChem	9886079
UNII	MU9089C77W^Y
InChI InChI=1S/C19H26N2O4S/c1-19(2)10-6-9-14(18(25)21(19)12-16(22)23)20-17(24)15(26)11-13-7-4-3-5-8-13/h3-5,7-8,14-15,26H,6,9-12H2,1-2H3,(H,20,24)(H,22,23)/t14-,15-/m0/s1^Y Key: YRSVDSQRGBYVIY-GJZGRUSLSA-N^Y
SMILES O=C1N(CC(=O)O)C(CCC[C@@H]1NC(=O)[C@@H](S)Cc2ccccc2)(C)C
Properties
Chemical formula	C₁₉H₂₆N₂O₄S
Molar mass	378.49
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Gemopatrilat is a drug which acts as an vasopeptidase inhibitor.^[1]^[2]

References

↑ Laverman GD, Van Goor H, Henning RH, De Jong PE, De Zeeuw D, Navis G (January 2003). "Renoprotective effects of VPI versus ACEI in normotensive nephrotic rats on different sodium intakes". Kidney International. 63 (1): 64–71. doi:10.1046/j.1523-1755.2003.00708.x. PMID 12472769.
↑ Wait JC, Vaccharajani N, Mitroka J, Jemal M, Khan S, Bonacorsi SJ, Rinehart JK, Iyer RA (June 2006). "Metabolism of [14C]gemopatrilat after oral administration to rats, dogs, and humans". Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34 (6): 961–70. doi:10.1124/dmd.105.007500. PMID 16540589.

Antihypertensives: agents acting on the renin–angiotensin system (C09)

ACE inhibitors ("-pril")	Sulfhydryl-containing: Captopril Rentiapril Zofenopril Dicarboxylate-containing: Enalapril^# Benazepril Cilazapril Delapril Imidapril Lisinopril (+HCT) Moexipril Perindopril (+indapamide) Quinapril (+HCT) Ramipril Spirapril Temocapril Trandolapril Phosphonate-containing: Fosinopril (+HCT) Other/ungrouped: Alacepril

AIIRAs ("-sartan")	Azilsartan Candesartan Eprosartan Fimasartan Irbesartan Losartan (+HCT) Olmesartan (+amlodipine) Tasosartan^§ Telmisartan (+HCT) Valsartan (+HCT, +amlodipine, +sacubitril)

Renin inhibitors ("-kiren")	Aliskiren (+amlodipine, +amlodipine and HCT) Remikiren^§

^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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