Dihydropyrimidine dehydrogenase

dihydropyrimidine dehydrogenase
Identifiers
Symbol	DPYD
Entrez	1806
HUGO	3012
OMIM	274270
RefSeq	NM_000110
Other data
EC number	1.3.1.2
Locus	Chr. 1 p22

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.

External links

Purine metabolism

Anabolism

R5P→IMP:	Ribose-phosphate diphosphokinase Amidophosphoribosyltransferase Phosphoribosylglycinamide formyltransferase AIR synthetase (FGAM cyclase) Phosphoribosylaminoimidazole carboxylase Phosphoribosylaminoimidazolesuccinocarboxamide synthase IMP synthase

IMP→AMP:	Adenylosuccinate synthase Adenylosuccinate lyase reverse AMP deaminase

IMP→GMP:	IMP dehydrogenase GMP synthase reverse GMP reductase

Nucleotide salvage

Catabolism

Pyrimidine metabolism

Anabolism

CAD Carbamoyl phosphate synthase II Aspartate carbamoyltransferase Dihydroorotase

Dihydroorotate dehydrogenase Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase

CTP synthetase

Catabolism

Deoxyribonucleotides

This article is issued from Wikipedia - version of the 3/15/2013. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

Dihydropyrimidine dehydrogenase

See also

External links