Cinchocaine
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | topical, intravenous (equine euthanasia) |
| ATC code | C05AD04 (WHO) D04AB02 (WHO) N01BB06 (WHO) S01HA06 (WHO) S02DA04 (WHO) |
| Legal status | |
| Legal status |
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| Identifiers | |
| |
| CAS Number |
85-79-0  |
| PubChem (CID) | 3025 |
| IUPHAR/BPS | 7159 |
| DrugBank |
DB00527 |
| ChemSpider |
2917 |
| UNII |
L6JW2TJG99 |
| KEGG |
D00733 |
| ChEBI |
CHEBI:247956 |
| ChEMBL |
CHEMBL1086 |
| ECHA InfoCard | 100.001.484 |
| Chemical and physical data | |
| Formula | C20H29N3O2 |
| Molar mass | 343.463 g/mol |
| 3D model (Jmol) | Interactive image |
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| (verify) | |
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
See also
References
Further reading
- Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco. 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padron T, Lima AP, de Oliveira Ribeiro R (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res. 99 (4): 317–20. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm. 62 (5): 369–79. PMID 16459486.
- Aroti, A.; Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment .". Journal of Chemical Education. 78 (6): 786–788. doi:10.1021/ed078p786.
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