Chlorproguanil

Chlorproguanil
Names

IUPAC name 1-[Amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine
Identifiers
CAS Number	537-21-3^Y
3D model (Jmol)	Interactive image
ChemSpider	20950^N
ECHA InfoCard	100.007.875
PubChem	22323
UNII	8O3249M729^Y
InChI InChI=1S/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18)^N Key: ISZNZKHCRKXXAU-UHFFFAOYSA-N^N InChI=1/C11H15Cl2N5/c1-6(2)16-10(14)18-11(15)17-7-3-4-8(12)9(13)5-7/h3-6H,1-2H3,(H5,14,15,16,17,18) Key: ISZNZKHCRKXXAU-UHFFFAOYAU
SMILES Clc1ccc(NC(=N/C(=N/C(C)C)N)N)cc1Cl
Properties
Chemical formula	C₁₁H₁₅Cl₂N₅
Molar mass	288.18 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Chlorproguanil is an antimalarial drug.

See also

Antiparasitics – antiprotozoal agents – Chromalveolate antiparasitics (P01)

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)

Isosporiasis	trimethoprim/sulfamethoxazole^#

Toxoplasmosis	pyrimethamine sulfadiazine

Individual
agents

Hemozoin
inhibitors

Aminoquinolines	(4-): amodiaquine^# chloroquine^# hydroxychloroquine^# (8-): primaquine^# pamaquine^‡ tafenoquine^†

4-Methanolquinolines	mefloquine^# quinine^# quinidine

Other	lumefantrine + artemether^# halofantrine

DHFR inhibitors	pyrimethamine biguanides chlorproguanil proguanil^#

Sulfonamides	sulfadoxine sulfalene

Co-formulation	sulfadoxine/pyrimethamine (SP)^#

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine^# arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine dihydroartemisinin/piperaquine

Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

clindamycin

Balantidiasis: tetracycline

Blastocystosis: metronidazole

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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