Bromodifluoroacetyl chloride
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| Names | |
|---|---|
| Preferred IUPAC name
Bromo(difluoro)acetyl chloride | |
| Other names
2-Bromo-2,2-difluoroacetyl chloride 2-Bromo-2,2-difluoro-ethanoyl chloride | |
| Identifiers | |
3832-48-2  | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 454349 |
| ECHA InfoCard | 100.197.413 |
| PubChem | 520892 |
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| Properties | |
| C2BrClF2O | |
| Molar mass | 193.37 g·mol−1 |
| Appearance | liquid |
| Boiling point | 50 °C (122 °F; 323 K) |
| Hazards | |
| Safety data sheet | |
| EU classification (DSD) |
Corrosive (C) |
| R-phrases | R34 |
| S-phrases | S36/37/39, S45 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Bromodifluoroacetyl chloride is a chemical compound with the formula BrCF2COCl. It has been used as a starting material for the synthesis of (biologically active) α,α-difluoro-γ-lactams[1] and has been used in the synthesis of trifluoromethylated C-nucleosides.[2]
References
- ↑ Nagashima, H.; Isono, Y.; Iwamatsu, S. (2001). "Copper-Catalyzed Cyclization of N-Allylhalodifluoroacetamides: An Efficient Synthesis of α,α-difluoro-γ-lactams". Journal of Organic Chemistry. 66 (1): 315–319. doi:10.1021/jo001187f.
- ↑ Mamata, C.; Heina, M.; Miethchen, R. (2006). "Fluorinated acyclo-C-nucleoside analogues from glycals in two steps". Carbohydrate Research. 341 (10): 1758–1763. doi:10.1016/j.carres.2006.01.011. PMID 16442508.
See also
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