2'-Deamino-2'-hydroxyneamine transaminase

2'-Deamino-2'-hydroxyneamine transaminase (EC 2.6.1.94, kacL (gene)) is an enzyme with systematic name 2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase.^[1] This enzyme catalyses the following chemical reaction

2'-deamino-2'-hydroxyneamine + 2-oxoglutarate

\rightleftharpoons

2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate

The reaction occurs in vivo in the opposite direction.

References

↑ Park, J.W.; Park, S.R.; Nepal, K.K.; Han, A.R.; Ban, Y.H.; Yoo, Y.J.; Kim, E.J.; Kim, E.M.; Kim, D.; Sohng, J.K.; Yoon, Y.J. (2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nat. Chem. Biol. 7: 843–852. doi:10.1038/nchembio.671. PMID 21983602.

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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